The clinical gold standard for androgenetic alopecia. 5-alpha reductase inhibitor backed by 25+ years of evidence and millions of prescriptions worldwide. Addresses the root cause, not the symptom.
Finasteride 1mg is a DHT-inhibitor proven to slow and reverse androgenetic alopecia through 5-alpha reductase blockade. Standard dosing is 1mg daily; baseline and 3–6-month monitoring (liver, PSA) ensures safety and efficacy tracking.
| Timepoint | Tests | Key Markers |
|---|---|---|
| Baseline (Week 0) | Liver panel, PSA, CBC | ALT, AST, PSA, WBC |
| 3 months | Liver panel, PSA | ALT, AST, PSA (trend) |
| 6 months | Liver panel, PSA, clinical photo | Efficacy assessment, liver safety |
| 12 months & annual | Liver, PSA, clinical photo | Maintenance phase, ongoing safety |
Androgenetic alopecia (male pattern baldness) is driven by DHT (dihydrotestosterone) sensitivity in genetically susceptible hair follicles. Finasteride addresses the root cause by blocking the enzyme that converts testosterone to DHT, slowing and reversing hair loss in the scalp.
Finasteride is well-absorbed orally and exhibits tight, irreversible enzyme binding to type II 5-alpha reductase. Despite a short plasma half-life, DHT suppression lasts 24+ hours due to enzyme saturation kinetics and slow enzyme turnover (requiring new protein synthesis for recovery).
| Bioavailability | ~80% (oral) |
| Tmax (time to peak) | 1–2 hours |
| Plasma half-life | 5–6 hours |
| Enzyme half-life (DHT suppression) | 24+ hours (despite short plasma t½ due to tight binding) |
| Protein binding | ~90% |
| Metabolism | Hepatic — CYP3A4. Two metabolites; minimal activity. |
| Excretion | Renal 39%, fecal 57% |
| Food effect | No significant effect on absorption; can take with or without food |
Finasteride for androgenetic alopecia has a fixed standard dose. Dosing is straightforward; efficacy depends on consistency, duration, and genetic responsiveness. Your dermatologist will assess if finasteride alone or combined therapy is optimal.
Finasteride for male pattern baldness is exceptionally well-studied, with multiple large RCTs and meta-analyses supporting efficacy and safety. It remains the gold-standard pharmacological treatment.
Finasteride's safety profile is favorable, with side effects rare and typically reversible. Sexual side effects (reported in <1–3% of users in RCTs) remain the primary concern, though causation vs. coincidence in older men remains debated.
Finasteride undergoes CYP3A4 metabolism but is not a significant CYP inducer or inhibitor at the 1mg dose. Drug interactions are minimal. No evidence of significant interactions with hormone-based medications at dermatologic doses.
Book a consultation with a physician to discuss whether finasteride is appropriate for your hair loss. The evidence is strong — the results take time.