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Longevity

Metformin ER

Metformin Hydrochloride 500mg/1000mg · Multiple manufacturers · Schedule H

The longevity community's most-studied molecule. 60+ years of safety data, AMPK activator, central to the landmark TAME (Targeting Aging with Metformin) trial. Taken by Peter Attia, David Sinclair, and every serious longevity researcher.

₹499
/month
Includes doctor consultation, prescription, medication & delivery
Have questions? Chat with us on WhatsApp
How your protocol works
1
Purchase
Secure checkout via Razorpay
2
Doctor calls
Licensed physician within 2hrs
3
Rx issued
Prescription after evaluation
4
Ships
Delivered within 48hrs
Half-life
6.2 hours
Dose Range
500–2000mg/day
Safety Record
60+ years
Schedule
H (Rx)
Pharmacology

How metformin works

Metformin activates AMPK—the master cellular energy sensor—mimicking caloric restriction at the molecular level. This shifts cells from anabolic growth mode to catabolic maintenance and repair. The mechanisms are well-characterized and supported by decades of research across species.

AMPK Activation
Activates the master cellular energy sensor, mimicking caloric restriction. AMPK is upstream of cellular survival and longevity pathways.
mTOR Inhibition
Downstream suppression of mTOR pathway—the growth regulator linked to lifespan extension in model organisms from yeast to primates.
Mitochondrial Efficiency
Mild inhibition of Complex I improves mitochondrial efficiency and reduces ROS production, protecting cellular components from oxidative damage.
Evidence

Clinical data

Metformin has the most robust evidence base of any longevity intervention in humans. The TAME trial, currently enrolling 3,000 participants, will be the first large-scale randomized controlled trial specifically testing longevity effects. Observational data suggests substantial benefits.

30%
Reduced all-cause mortality
Observational studies (non-diabetic cohorts)
31%
Diabetes risk reduction
Diabetes Prevention Program (DPP) trial
3,000+
Participants in TAME trial
Targeting Aging with Metformin (ongoing)
Protocol

How to get started

01
Book Consultation
Connect with a licensed physician via WhatsApp
02
Medical Evaluation
Doctor reviews your health, goals, and contraindications
03
Prescription
If medically appropriate, prescription is issued
04
Delivered
Ships from licensed pharmacy within 24 hours
FAQ

Common questions

Why do longevity researchers take metformin?
Because it's the only drug with genuine longevity track record in humans. It activates AMPK, inhibits mTOR, and observational data shows 30% mortality reduction in non-diabetics. The TAME trial will provide definitive evidence.
Is it safe for non-diabetics?
Yes. Metformin has 60+ years of safety data across millions of patients. Non-diabetic use at modest doses (500-2000mg/day) is well-tolerated. Common side effects (GI upset) are usually dose-dependent and resolve with extended-release formulations.
What about side effects?
Most common are GI-related (nausea, diarrhea, loss of appetite), especially at high doses or immediate-release formulations. ER versions minimize this. Vitamin B12 absorption can decrease with long-term use—monitor levels. Serious side effects are rare.
Does metformin interact with exercise?
Interestingly, some evidence suggests metformin may blunt acute mitochondrial adaptations to intense training. This is debated. Most athletes use it without issues. Discuss timing with your physician if you're doing serious endurance training.
What's the TAME trial status?
TAME (Targeting Aging with Metformin) is recruiting healthy adults 65+ across multiple US sites. It's a 6-year RCT testing whether metformin delays time to major age-related diseases. Results expected early 2030s. This will be landmark longevity data.
What's included in the ₹499/month protocol price?
The monthly protocol price includes the doctor consultation, prescription issuance after health evaluation, metformin ER 500mg/1000mg medication (typically a month's supply), and delivery to your door within 48 hours. No hidden fees—what you see is what you pay. Your doctor will adjust dosage based on your individual needs.
Get Started

Ready to optimize?

Book a consultation with a licensed physician to discuss whether metformin ER is appropriate for your longevity protocol.

Have questions? Chat with us on WhatsApp