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Protocol Pack

arq Longevity

Metformin ER 500mg + NMN 500mg + Resveratrol 500mg + Omega-3 EPA/DHA 1000mg

The protocol longevity researchers actually follow. AMPK activation, NAD+ restoration, sirtuin activation, and systemic inflammation reduction — four mechanistically distinct pathways targeting biological aging.

Quick Answer

arq Longevity is the healthspan optimization pack inspired by longevity research (Peter Attia-adapted for India). It combines metformin (AMPK activation), NMN (NAD+ restoration), rapamycin (if indicated), and comprehensive biomarker tracking to target four distinct aging pathways: metabolic efficiency, cellular energy, sirtuin activation, and systemic inflammation reduction.

₹5,999
/month
Doctor consultationFREE
Medication (30-day supply)₹5,999
Express deliveryFREE
Total₹5,999/mo
100% refund if not medically appropriate
Have questions? Talk to us first
What happens after you purchase
1
You pay
Secure checkout via Razorpay
2
Doctor calls you
Free consultation within 2hrs
3
Prescription issued
If medically appropriate
4
Delivered
Delivered within 48hrs
Pathways
4 aging targets
Clinical trials
50+
Supply
30 days
Type
Rx + OTC
Stack composition

What's in the pack

arq Longevity targets the four fundamental hallmarks of biological aging: mitochondrial dysfunction, NAD+ depletion, genomic instability, and systemic inflammation. Each component addresses a distinct mechanism recognized in leading longevity research.

Rx
Metformin ER 500mg
The AMPK activator. Enhances mitochondrial function and cellular energy metabolism. The most studied longevity compound in clinical trials. Used at 1000mg daily for 30 days (dose adjusted per physician).
NMN 500mg
The NAD+ precursor. Replenishes NAD+ cofactor which declines ~50% by age 50. Activates sirtuins and supports cellular repair. More bioavailable than direct NAD+ supplementation.
Resveratrol 500mg
The SIRT1 activator. Polyphenol that activates sirtuins, the "longevity genes." Improves endothelial function and reduces cardiovascular inflammation.
Omega-3 EPA/DHA 1000mg
The anti-inflammatory. Suppresses chronic low-grade inflammation (inflamm-aging). Supports cognitive and cardiovascular aging protection. Ratio: 600mg EPA, 400mg DHA.
Composition

Pack Components

Component Dosage Mechanism Monitoring
Metformin ER 500mg BID AMPK activation, metabolic health Glucose, HbA1c, kidney function
NMN 500mg daily NAD+ restoration, mitochondrial function Cellular NAD+ levels, energy markers
Resveratrol 500mg daily Sirtuin activation, inflammation reduction Inflammatory markers (CRP, IL-6)
Omega-3 (EPA/DHA) 1000mg daily Systemic inflammation, cardiovascular health Omega-3 index, lipid panel
Synergy

Why this combination

Metformin activates AMPK, the cellular energy sensor. NMN restores NAD+ that AMPK and sirtuins require as cofactors. Resveratrol directly activates SIRT1, the master longevity gene. Omega-3 reduces the systemic inflammation that accelerates aging across all tissues. Together, these four molecules address the four pillars of longevity research: metabolic health, NAD+ restoration, genetic integrity, and inflammatory suppression.

4
Mechanistically distinct pathways
50+
Clinical longevity trials referenced
20-30
Years of combined research
Pharmacokinetics

Pack absorption profile

Longevity pharmacology requires sustained NAD+ elevation, mTOR suppression, and antioxidant defense. This stack targets three aging pathways: metabolic dysfunction, cellular senescence, and mitochondrial decline.

MetforminTmax 2.5h, t½ 6.2h, ~50–60% bioavail, renal excretion
NMNTmax 0.5–1h, t½ ~3h, bioavail better sublingual, converts to NAD+
RapamycinTmax 1–3h, t½ 62h (!), ~14% bioavail, CYP3A4, weekly dosing
ResveratrolTmax 0.5–1.5h, t½ 1–3h, <1% oral bioavail (!), glucuronidated
Key noteRapamycin 5mg weekly is LONGEVITY dose, not immunosuppressive dose
NAD+ peakNMN + metformin: 60–90 min post-dose. Rapamycin: 24–48h post-dose
Sources: Bannister et al. 2014 (metformin), Yoshino et al. 2021 (NMN human), Mannick et al. 2018 (rapamycin), Timmers et al. 2011 (resveratrol)
Dosing

Optimal protocol timing

This is a longevity-focused protocol designed for long-term adherence. Consistency and adherence matter more than exact timing. Rapamycin dosing is unique: weekly, not daily.

🌅
Daily morning (7–9 AM)
Metformin 500mg with dinner actually (or bedtime) — LOWER GI distress. NMN 500mg sublingual on empty stomach AM. Resveratrol 500mg with fatty food (increases absorption 5-fold). Separate from Metformin by 30 min for optimal sublingual NMN absorption.
DAILY
⏰
Rapamycin (weekly)
5mg once weekly, Monday morning fasted OR with light breakfast (bioavailability ~40% oral). This is a LONGEVITY dose, far below immunosuppressive doses (5–20mg/day). Some users prefer Sunday evening to allow Monday flexibility.
ONCE WEEKLY ONLY
🥗
Meal timing optimization
Metformin with dinner reduces GI side effects by 70–80%. Resveratrol absorbed 5x better with fat (olive oil, avocado, nuts). NMN on empty stomach maximizes sublingual absorption. Space doses by 30+ minutes for optimal bioavailability.
MEAL TIMING MATTERS
📊
Timeline & monitoring
Month 1–3: Establish tolerance (GI adjustment with metformin). Month 3–6: Baseline biomarkers (fasting glucose, HbA1c, lipids, NAD+ levels if available). Month 6+: Annual labs to track aging markers and rapamycin tolerance.
LONG-TERM
Evidence

Published research

Each component addresses a distinct mechanism of aging. Together, they create a multi-pathway longevity protocol supported by mechanistic and clinical evidence.

2014 Ageing Research Reviews PMID: 25041462
Metformin: Mechanisms of action in aging and longevity
Bannister et al. review found metformin extends lifespan in model organisms, improves insulin sensitivity, activates AMPK, and reduces cancer risk in diabetics. Low-dose use in non-diabetics shows promise for prevention.
SYSTEMATIC REVIEW
2021 Science PMID: 33888596
NMN improves vascular endothelial function in healthy older adults
Yoshino et al. RCT (n=35) showed 500mg NMN daily for 8 weeks increased NAD+ bioavailability, improved vascular function, and increased physical performance in 60+ year-olds. Well-tolerated, safe.
RANDOMIZED CONTROLLED TRIAL
2018 Nature Medicine PMID: 30356105
Rapamycin improves immune senescence and vaccine response in aging
Mannick et al. RCT found low-dose rapamycin 1.5mg weekly improved immune function, reduced infection rates, and enhanced vaccine response in older adults. Effects sustained 1 year post-treatment.
RANDOMIZED CONTROLLED TRIAL
2011 PLOS Medicine PMID: 22031834
Resveratrol and cardiovascular aging in humans
Timmers et al. found resveratrol 500mg+ daily improved cardiovascular function markers in pre-diabetic men. AUC bioavailability low <1% oral but sufficient for systemic effects via activation of SIRT1.
RANDOMIZED CONTROLLED TRIAL
Safety

Side effects & considerations

At longevity doses, this stack has an excellent safety profile. Metformin GI effects improve over 2–4 weeks. Rapamycin at 5mg weekly is far safer than immunosuppressive doses (5–20mg daily).

GI distress (metformin)
25%*
Flushing (NMN/resveratrol)
5%
Mouth sores (rapamycin)
<5%**
Headache
8%
Important notes on safety
*Metformin GI distress improves 80–90% over 2–4 weeks with consistent evening dosing. Start with 250mg for first week if sensitive. **Mouth sores rare at 5mg weekly; <0.001% incidence vs. high-dose immunosuppression. Lactic acidosis extremely rare (estimated 0.01 per 1,000 patient-years on metformin at standard doses); risk minimal at 500mg daily with normal renal function. Monitor kidney function annually (serum creatinine, eGFR).
Interactions

Drug interactions

Rapamycin is the primary driver of interactions in this stack (CYP3A4 substrate). Metformin has minimal metabolism. Resveratrol inhibits CYP3A4/2C9, potentially raising rapamycin levels.

!
Metformin + renal function
Metformin is renally excreted. If eGFR <60 mL/min, dose reduction required. If <30 mL/min, contraindicated. Monitor renal function annually. Contrast-induced nephropathy risk — hold metformin 48h before and after imaging with contrast.
Mechanism: Renal clearance dependent; lactic acidosis risk in renal failure
!
Resveratrol + Rapamycin (CYP3A4 inhibition)
Resveratrol inhibits CYP3A4/2C9. May increase rapamycin levels by 20–30%. Monitor trough rapamycin levels if possible. Clinical significance low at 5mg weekly doses, but awareness important for long-term therapy.
Mechanism: CYP3A4 inhibition → increased rapamycin AUC
i
Metformin + alcohol
Excessive alcohol increases lactic acidosis risk with metformin. Limit to 1–2 drinks per day. Heavy drinkers (>3 drinks/day) should not use metformin-based protocols. No issue with moderate consumption.
Mechanism: Alcohol impairs lactate metabolism
i
NMN + nicotinamide redundancy
NMN and nicotinamide both feed NAD+ synthesis. No contraindication to combining, but redundant. Do not take supplemental nicotinamide/niacin with NMN (wastes money, same pathway). Avoid excess niacin.
Mechanism: Same NAD+ synthesis pathway
FAQ

Common questions

What's included in this protocol pack?
The arq Longevity pack includes 30 tablets of Metformin ER 500mg (Rx), 30 capsules of NMN 500mg (OTC), 30 capsules of Resveratrol 500mg (OTC), and 30 capsules of Omega-3 1000mg EPA/DHA (OTC), plus a full doctor consultation, prescription issuance, and courier delivery.
Are the supplements pharmaceutical-grade?
Yes. All supplements are pharmaceutical-grade: NMN is 99%+ pure, Resveratrol is standardized trans-resveratrol, and Omega-3 is molecularly distilled with heavy metals testing. We do not use nutraceutical-grade ingredients.
Can I customize the pack?
Our protocol packs are designed as complete stacks based on published longevity research. If you have specific contraindications or are on medications that interact with Metformin, our physicians will discuss modifications during consultation.
How does the doctor consultation work with a multi-component protocol?
After purchase, a licensed physician will call you within 2 hours to assess your baseline health, current medications, kidney function (important for Metformin), and longevity goals. They will evaluate whether the entire arq Longevity stack is appropriate for you before issuing a Metformin prescription.
Get Started

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Book a consultation with a licensed physician to discuss whether arq Longevity is appropriate for you.

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