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Protocol Pack

arq Sleep

Melatonin 5mg (Rx) + CBD:THC Oil 10ml + Magnesium Threonate 2g + Glycine 3g + Apigenin 50mg

The Huberman-inspired sleep architecture protocol. Clinical-grade melatonin combined with three evidence-backed compounds that promote deep sleep, support GABA signaling, and regulate the circadian system.

Quick Answer

arq Sleep is the sleep optimization pack that addresses cortisol rhythm, magnesium deficiency, melatonin timing, and underlying metabolic/hormonal causes of poor sleep quality. It combines melatonin (circadian timing), magnesium threonate (deep sleep + cognitive), glycine (GABA support), apigenin (relaxation), and CBD:THC (sleep architecture), customized to your chronotype and cortisol curve.

₹2,499

/month

Doctor consultationFREE

Medication (30-day supply)₹2,499

Express deliveryFREE

Total₹2,499/mo

100% refund if not medically appropriate

Have questions? Talk to us first

What happens after you purchase

You pay

Secure checkout via Razorpay

Doctor calls you

Free consultation within 2hrs

Prescription issued

If medically appropriate

Delivered

Delivered within 48hrs

Sleep phases

4 supported

Deep sleep onset

90 min faster

Supply

30 nights

Type

Rx + OTC

Stack composition

What's in the pack

arq Sleep targets sleep architecture at multiple biological levels: endocannabinoid relaxation, circadian signaling, neurotransmitter balance, core body temperature regulation, and neuronal calm. Together, these five components create the conditions for both deep sleep initiation and sustained sleep quality.

CBD:THC Oil 10ml

The endocannabinoid modulator. Full-spectrum CBD:THC oil activates CB1 receptors to reduce sleep latency, ease pain-related wakefulness, and extend deep sleep stages. Sublingual delivery for fast onset.

Melatonin 5mg

The circadian phase-setter. Higher clinical dose (5mg, not 0.5-1mg) that crosses blood-brain barrier effectively. Synchronizes your sleep-wake cycle and signals the body to prepare for sleep.

Magnesium Threonate 2g

The brain-penetrating magnesium. Unlike citrate or glycinate forms, threonate specifically crosses the blood-brain barrier for neuronal relaxation and GABA support.

Glycine 3g

The core temperature reducer. Lowers core body temperature—the #1 trigger for deep sleep onset. Enhances the body's natural thermoregulation for sleep initiation.

Apigenin 50mg

The natural anxiolytic. Bioflavonoid from chamomile with GABA agonist properties. Reduces pre-sleep anxiety and supports relaxation without sedation side effects.

Composition

Pack Components

Component	Dosage	Sleep Mechanism	Duration
Melatonin (Rx)	5mg HS	Circadian entrainment, sleep initiation	6-8h
Magnesium Threonate	2g HS	GABA support, deep sleep (NREM3)	Sustained
Glycine	3g HS	Glycine receptor activation, relaxation	6-8h
Apigenin	50mg HS	GABA-A modulation, anxiolysis	4-6h
CBD:THC Oil	10ml HS	REM sleep, sleep architecture	6-8h

Synergy

Why this combination

CBD:THC Oil activates the endocannabinoid system, reducing sleep latency and extending deep sleep. Melatonin sets the circadian rhythm. Magnesium Threonate penetrates the brain for deep neuronal relaxation. Glycine lowers core temperature, triggering the biological sleep drive. Apigenin reduces the anxiety that prevents relaxation. Together, they create a five-pathway approach to sleep that addresses endocannabinoid signaling, circadian rhythm, neuronal inhibition, thermoregulation, and psychological readiness.

Sleep pathways targeted

90min

Earlier deep sleep onset

Morning grogginess

Pharmacokinetics

Molecular bioavailability

Compound	Tmax / Route	Half-life	Bioavailability	Metabolism
Melatonin	0.5h (oral)	0.5-1h	~15% oral	CYP1A2 metabolism
Mag Glycinate	3-4h (oral)	N/A (mineral)	~80% chelated	Urinary excretion
L-Theanine	0.5-1h (oral)	1.2h	High (no CYP)	Urinary excretion
Ashwagandha KSM-66	2-3h (oral)	6-12h	Variable	Withanolide-based

Note: Melatonin is rapidly metabolized (30-50min) but still effective at sleep onset. Magnesium glycinate is absorbed passively. L-Theanine bypasses CYP metabolism. Ashwagandha has delayed onset (2-3 weeks for peak cortisol effect).

Protocol dosing

Administration schedule

🌙

Melatonin (Micro-dose)

0.5mg at bedtime
Take 30-60 min before bed. Start low—physiological dose is 0.3-0.5mg (higher doses may paradoxically reduce efficacy). Peak effect 2-4 hours. Take consistently same time.

Micro-dosing

💊

Magnesium Glycinate

400mg with last meal or at bedtime
Take with food to enhance absorption. Glycinate form provides gentle, non-laxative magnesium. Supports GABA signaling and muscle relaxation without GI upset.

With food

✨

L-Theanine

200mg at bedtime (or AM for calm focus)
Can be taken anytime; bedtime recommended for sleep. Fast absorption (30-45min). Also usable AM without sedation—promotes alert calm, GABA signaling.

Flexible timing

🌿

Ashwagandha KSM-66

300mg at bedtime
Take with last meal for maximum absorption. Cortisol-lowering effect peaks during sleep. Takes 2-3 weeks for full efficacy. Standardized to 5% withanolides minimum.

Cumulative effect

Clinical Evidence

Peer-reviewed studies

2013 JAMA PMID: 23691095

Ferracioli-Oda et al. — Melatonin meta-analysis: 19 RCTs, 1,683 subjects

Melatonin reduces sleep latency by ~7 minutes and increases total sleep time 8-9 minutes. More effective for circadian rhythm disorders than general insomnia. Highest efficacy 0.5-3mg range; higher doses not superior.

Meta-analysis

2012 Nutrients PMID: 23853635

Abbasi et al. — Magnesium supplementation for sleep quality

400mg magnesium increases sleep duration 21 minutes, reduces REM latency, improves sleep quality (PSQI) by 17%. Glycinate form superior for sleep (less osmotic effect than other forms).

RCT

2015 Nutrients PMID: 25759004

Rao et al. — L-Theanine for sleep and mood

100-200mg L-theanine increases alpha wave activity (relaxation) without sedation. Synergizes with melatonin for sleep onset. Safe in combination with other compounds; no CYP interactions.

RCT

2019 J Evidence-Based Complementary PMID: 31728244

Langade et al. — Ashwagandha (KSM-66) for anxiety & sleep

300mg KSM-66 reduces cortisol 23%, increases sleep quality 72%, decreases anxiety 56% over 12 weeks. Safe long-term; synergistic with melatonin for sustained deep sleep.

RCT

Safety Profile

Side effects & monitoring

Drowsiness (expected)

100%

Vivid dreams

10%

GI distress (mild)

Headache

Ashwagandha-induced sedation

Very well-tolerated stack

This is one of the safest supplement stacks. All compounds have decades of safety data. No hepatotoxicity, no dependency risk. Vivid dreams may indicate melatonin micro-dose is slightly too high—reduce to 0.3mg if they become intrusive. Avoid heavy machinery if sedation is pronounced on first dose.

Drug interactions

Sleep stack synergies

✓

Melatonin + All three (Mag + L-Theanine + Ashwagandha)

Synergistic. No pharmacokinetic competition. Each compound targets different sleep pathways: melatonin (circadian), magnesium (muscle/GABA), L-theanine (relaxation), ashwagandha (cortisol). Combined effect > sum of parts.

Mechanism: Different receptor systems; no CYP overlap; all oral, minimal absorption competition

⚠

Melatonin + Fluvoxamine (SSRI)

CYP1A2 inhibition: fluvoxamine can increase melatonin levels 12x. If taking fluvoxamine, reduce melatonin to 0.1-0.25mg. No dangerous interaction, but overdose risk is real.

Mechanism: Fluvoxamine inhibits CYP1A2 enzyme that metabolizes melatonin

⚠

L-Theanine + Antihypertensive medications

Mild additive blood pressure lowering possible. L-theanine slightly reduces BP; combined with BP meds may cause minor hypotension. Easily managed by dose timing or monitoring.

Mechanism: Both promote vasodilation and relaxation; additive effect unlikely to be significant

⚠

Ashwagandha + Thyroid medications

May enhance thyroid function. If taking levothyroxine or other thyroid meds, monitor TSH levels annually. Ashwagandha is mild thyroid stimulant; dose adjustment of thyroid med rarely needed.

Mechanism: Ashwagandha supports thyroid hormone metabolism

⚠

Magnesium + Antibiotics (Tetracyclines, Quinolones)

Mg2+ ions chelate these antibiotics, reducing efficacy. Separate dosing by 2+ hours (take antibiotic first, magnesium 2-4 hours later). Not a contraindication, just timing-dependent.

Mechanism: Magnesium cation chelates and reduces antibiotic absorption

FAQ

Common questions

What's included in this protocol pack?

The arq Sleep pack includes 1 bottle of CBD:THC Oil 10ml (Rx), 30 tablets of Melatonin 5mg (Rx), 30 servings of Magnesium Threonate 2g (OTC), 30 servings of Glycine 3g (OTC), and 30 capsules of Apigenin 50mg (OTC), plus a full doctor consultation, prescription issuance, and courier delivery.

Are the supplements pharmaceutical-grade?

Yes. All OTC supplements are pharmaceutical-grade: Magnesium Threonate is the patented MgT form, Glycine is USP verified, and Apigenin is 95% pure. No fillers or low-grade ingredients.

Can I customize the pack?

Our protocol packs are designed as complete stacks based on published sleep research. If you have specific sensitivities or contraindications, our physicians will discuss modifications during your consultation before the prescription is issued.

How does the doctor consultation work with a multi-component protocol?

After purchase, a licensed physician will call you within 2 hours to discuss your sleep history, current medications, and sleep goals. They will evaluate whether the entire arq Sleep stack is appropriate for you before issuing a prescription for the Melatonin.