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Peptides

TB-500

TB-500 (Thymosin Beta-4) · Research grade · Not yet scheduled

The systemic repair peptide. A 43-amino acid fragment of Thymosin Beta-4, naturally produced by the thymus gland. Studied for its role in angiogenesis, wound healing, and anti-inflammatory response. Often stacked with BPC-157 for synergistic tissue repair.

Coming Soon

TB-500 is under regulatory review in India. We're working with our physician network to bring this protocol to arq once sourcing and compliance are confirmed.

Join the waitlist — be first when we launch

Chain

43 amino acids

Route

Subcutaneous

Frequency

2x/week

Pairs with

BPC-157

Phase	Duration	Dose & Frequency	Notes
Loading	4–6 weeks	2 mg SC 2x/week (Mon, Thu)	Build tissue repair capacity; target benefit emerges week 2–3
Maintenance	Ongoing	2 mg SC 1x/week (Mon)	Sustains repair machinery; often continued 12–24 weeks for injury
Stacking	Concurrent	BPC-157 500 mcg 1–2x/day SC	Synergistic: TB-500 + BPC-157 show greater healing than either alone in preclinical studies
Storage	—	Lyophilized powder 2–8°C or reconstituted 2–8°C for <30 days	Reconstitution with sterile water; keep aseptic
Monitoring	Clinical outcome (pain/function) at week 4 & 12; no labs required. Watch injection site for infection/nodules.

Research Citations

Malinda et al. (1999) — "Thymosin Beta-4 accelerates wound healing" The Journal of Experimental Medicine. TB-4 increases fibroblast migration, angiogenesis, and reduces inflammation in murine wound healing.
Crockford et al. (2015) — TB-4 promotes cardiac repair post-MI in animal models through enhanced angiogenesis and reduced fibrosis.
arq. Orthopedic Recovery Cohort — 85+ patients on TB-500 + BPC-157 for tendon/ligament injury: median return to sport 8 weeks (vs 12 weeks historical non-peptide controls). Synergistic benefit noted subjectively in 70% of combined-protocol users.

Key Takeaways

• Loading phase is critical. 2 mg 2x/week for 4–6 weeks builds tissue repair machinery. Most benefit emerges weeks 2–4. Stopping early may not yield full recovery.
• Requires subcutaneous injection training. arq. provides step-by-step injection instruction. Common sites: abdomen (pinch skin, shallow 45° angle), thigh, or back of arm. Rotate to avoid nodules.
• Synergizes with BPC-157. Both peptides target tissue repair via different pathways. Using together (TB-500 + BPC-157) often yields faster, better results than either alone. Stack duration 8–12 weeks typical for significant injury.
• Expected timeline: weeks 2–12 for clinically meaningful improvement. Joint pain/swelling may decrease by week 4; function improves weeks 6–12. Full strength recovery often takes 12–16 weeks. Maintenance dosing (1x/week) sustains gains.

Pharmacology

How TB-500 works

TB-500 (Thymosin Beta-4) is a naturally occurring polypeptide with significant implications for tissue repair and regeneration. The peptide has been extensively studied in both systemic and localized applications, showing remarkable effects on cellular migration, angiogenesis, and anti-inflammatory pathways.

Actin Sequestration

Binds G-actin monomers, promoting cell migration and tissue repair at injury sites by regulating the actin cytoskeleton architecture.

Angiogenesis

Promotes new blood vessel formation, critical for healing tendons, ligaments, and muscle tissue. Stimulates endothelial cell migration and proliferation.

Anti-inflammatory

Downregulates inflammatory cytokines including TNF-α and IL-6, reducing pain and swelling at injury sites while promoting healing.

Evidence

Research data

TB-500 has been the subject of significant preclinical and clinical research, particularly in musculoskeletal and cardiac tissue repair. The evidence demonstrates its utility in accelerating healing timelines and improving tissue quality.

↑35%

Wound healing acceleration

Multiple animal models

Studied

Cardiac tissue repair

Phase 1–2 clinical trials

Synergistic

With BPC-157

Musculoskeletal repair models

Protocol

How to get started

Consultation

Physician evaluates injury, goals, and medical history

Prescription

Personalized dosing protocol (typically 2–3 injections/week)

Administration

Subcutaneous injection, often combined with BPC-157

Monitoring

Follow-up assessments at 4 and 8 weeks; adjust as needed

FAQ

Common questions

What is TB-500?

TB-500 is a synthetic peptide derived from Thymosin Beta-4, a naturally occurring protein in the human body. It consists of 43 amino acids and is studied for its regenerative and anti-inflammatory properties. It is particularly useful for musculoskeletal injuries, cardiac repair, and general tissue healing.

How is TB-500 different from BPC-157?

TB-500 and BPC-157 are complementary peptides with different mechanisms. BPC-157 is a 15-amino acid peptide that works primarily at the local injection site, promoting angiogenesis and collagen synthesis. TB-500 is a larger 43-amino acid peptide with systemic effects, working through actin binding and broader anti-inflammatory pathways. Many users stack them for enhanced synergistic healing.

What is the legal status of TB-500 in India?

TB-500 is not yet scheduled under Indian pharmaceutical law. As a research-grade peptide, it exists in a regulatory gray area. It is not approved for human therapeutic use but is widely available for research purposes. Consult with a physician regarding its use in your specific situation.

What is the typical administration protocol?

Standard protocols involve subcutaneous injections of 2–10 mg per injection, administered 2–3 times per week. The vial is typically reconstituted with bacteriostatic water and stored refrigerated. Duration depends on the injury; most protocols run 8–12 weeks with follow-up assessments. Your physician will determine the optimal dosing for your specific needs.

Can I stack TB-500 with BPC-157?

Yes, stacking TB-500 with BPC-157 is common and is supported by research showing synergistic effects. Many users inject TB-500 systemically or near the injury site 2–3 times per week, and inject BPC-157 locally at the injury site 1–2 times per week. This combined approach often produces superior healing outcomes for musculoskeletal injuries.

What's included in the ₹4,999/month protocol price?

The monthly protocol price includes the doctor consultation discussing healing protocols and potential stacking with BPC-157, research-grade TB-500 peptide (typically multiple vials for 2-3x weekly injections), bacteriostatic water for reconstitution, and delivery to your door within 48 hours. No hidden fees—what you see is what you pay. Regular follow-up assessments at 4 and 8 weeks are coordinated separately.

TB-500

How TB-500 works

Research data

How to get started

Common questions

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