Sexual health
Sexual Health · Routes to the Performance Panel

Low libido is a hormone panel away from answered.

Dr
Medically reviewed by arq. physicians
Board-certified doctors · Last reviewed April 2026 · Evidence-based content

Testosterone, SHBG, prolactin, thyroid, vitamin D — the markers your GP skips. Your endocrinologist reads them against South Asian ranges, then prescribes the Hormone Optimization Protocol if clinically justified. Video-gated, lab-monitored, CDSCO-compliant.

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The problem

Sexual dysfunction is self-treated

Most men reach for OTC pills, borrowed prescriptions, or supplements without ever testing. The truth: ED, low libido, premature ejaculation, and performance anxiety have measurable biological drivers. Testosterone is just the beginning. Prolactin suppresses desire. Thyroid dysfunction kills libido. Poor blood flow predicts ED. Cortisol (stress) sabotages performance. Without testing, treatment is guesswork.

Sexual Health Reality
ED prevalence in Indian men
30–40% of men under 40
Men who seek help
Less than 10% ever get tested
ED as a health warning
Predicts heart disease & stroke
Quick answer

Sexual dysfunction isn't one problem—it's a spectrum

Low libido, ED, PE, and post-orgasmic fatigue have different root causes—hormonal, vascular, neurological, or metabolic.
A comprehensive panel tests testosterone, prolactin, thyroid (TSH, T3, T4), estradiol, SHBG, DHEA-S, cortisol, glucose, lipids, and 90+ other markers. Your physician identifies the specific driver.
Most men improve dramatically once the root cause is identified and addressed—whether that's hormone optimization, cardiovascular support, stress management, or prescription therapy.
Sexual health is a biomarker of overall health. Fixing sexual dysfunction often improves energy, mood, metabolism, and cardiovascular health too.
The science

Markers we read for sexual health

These biomarkers reveal the biological drivers of sexual dysfunction — and what actually works to fix them.

Testosterone
Low T directly suppresses libido and erectile function
Free Testosterone
Bioavailable T determines sexual arousal and response
Prolactin
Elevated prolactin suppresses desire and erectile function
Thyroid (TSH, T3, T4)
Hypothyroidism kills libido; hyperthyroidism causes ED
Estradiol
Excess estradiol impairs erectile function and arousal
Cortisol
Chronic stress suppresses T, kills libido, causes ED
DHEA-S
Declining DHEA-S correlates with low sexual motivation
Blood Pressure + Lipids
Poor cardiovascular health = ED. Often reversible.
Glucose + Insulin
Diabetes and insulin resistance predict ED
SHBG
High SHBG traps testosterone, reducing bioavailable T
Inflammation (CRP)
Systemic inflammation impairs vascular and sexual function
Vitamin D, B12, Zinc
Micronutrient deficiencies directly impair sexual function
Complete panel

The sexual health biomarker panel

Your physician interprets each marker in context — they reveal the specific driver of your sexual dysfunction.

Marker What It Measures Why It Matters for Sexual Health
Total Testosterone All testosterone in blood Directly drives libido and erectile capacity. Low T = low desire and weak erections.
Free Testosterone Bioavailable testosterone The active form. High total T but low free T still causes ED and low libido.
Prolactin Hormone suppressing dopamine Elevated prolactin kills sexual desire and causes erectile dysfunction. Often overlooked.
TSH, Free T3, Free T4 Thyroid function Hypothyroidism suppresses libido and causes ED. Hyperthyroidism causes anxiety ED.
Estradiol Testosterone converts to estrogen High estradiol = soft erections and low sexual desire. Critical to monitor.
Cortisol (morning + evening) Stress hormone pattern Chronically elevated cortisol suppresses T, kills libido, and causes performance anxiety ED.
DHEA-S Androgen precursor hormone Low DHEA-S correlates with decreased sexual motivation and erectile weakness.
SHBG Sex hormone binding globulin High SHBG binds testosterone, leaving little free T available for sexual function.
Glucose + Insulin Metabolic health markers Diabetes and insulin resistance are major ED drivers. Often reversible with intervention.
Lipid Panel Cholesterol, triglycerides Abnormal lipids impair blood vessel function—the mechanical basis of erections.
Blood Pressure Systolic and diastolic Hypertension damages blood vessels and predicts ED. First sign of vascular disease.
Vitamin D, B12, Zinc, Magnesium Micronutrient status Deficiencies directly impair sexual function. Often corrected with supplementation.
Diagnosis

Sexual health conditions: root cause → treatment

Different sexual complaints have different biological drivers. Testing identifies what's actually wrong.

Condition
Erectile Dysfunction (ED)
Common Drivers
Low testosterone, poor blood flow (hypertension, high cholesterol), high prolactin, elevated cortisol, thyroid dysfunction, diabetes.
Treatment Approach
PDE5 inhibitors (sildenafil, tadalafil) + hormonal optimization + cardiovascular support + stress management.
Condition
Low Libido
Common Drivers
Low testosterone, elevated prolactin, hypothyroidism, high cortisol, depression, low vitamin D or zinc.
Treatment Approach
Testosterone optimization + prolactin management + thyroid support + stress reduction + micronutrient repletion.
Condition
Premature Ejaculation (PE)
Common Drivers
Low serotonin, high dopamine sensitivity, hyperthyroidism, performance anxiety, elevated cortisol.
Treatment Approach
Dapoxetine (SSRI for PE) + serotonin support (5-HTP, L-tryptophan) + thyroid correction + anxiety management.
Condition
Performance Anxiety
Common Drivers
Elevated cortisol, high prolactin, low DHEA-S, depression, sleep deprivation.
Treatment Approach
Stress management + sleep optimization + hormone rebalancing + therapy. Address the biology, not just the psychology.
Condition
Post-Orgasmic Fatigue
Common Drivers
Low testosterone, poor glucose control, magnesium deficiency, sleep apnea, low dopamine recovery.
Treatment Approach
Testosterone optimization + glucose control + magnesium repletion + sleep studies if indicated.

Why arq. for sexual health

Most "ED clinics"
Sell sildenafil or supplements without testing. No bloodwork. No diagnosis. You're just buying pills without understanding why you have ED.
arq. approach
Tests 100+ biomarkers: hormones, thyroid, metabolic markers, cardiovascular risk, inflammation. Your physician identifies the root cause—then treats it. Pills alone rarely fix the problem.
How it works

The arq. protocol for sexual health

Three steps. Your data. Your physician. Your protocol.

Blood test at home

100+ biomarkers drawn at your door in 10 minutes. NABL-accredited labs. Results in 5 days. No clinic visit, no waiting rooms — just comprehensive data about your sexual health.

Physician consult + diagnosis

Your physician reviews testosterone, prolactin, thyroid, cortisol, glucose, lipids, blood pressure, and 90+ other markers. Root cause identified—hormonal, vascular, neurological, or metabolic.

Your protocol, delivered

Prescription therapy (sildenafil, dapoxetine, hormone optimization) + lifestyle protocol + micronutrient optimization. Delivered in 48h. Retested at 8–12 weeks to verify results.

Member story
I tried sildenafil for months with no real improvement. Blood work showed prolactin was sky high, testosterone was low, and I had pre-diabetic glucose levels. Once we addressed all three, ED actually resolved. It was never just about the pill.
Summary

5 things you need to know

1. Sexual dysfunction has measurable causes. ED, low libido, and PE are rarely 'just in your head'. Low testosterone, high prolactin, thyroid dysfunction, poor blood flow, and stress hormones are the real drivers. Test first.
2. Sildenafil alone isn't the answer. PDE5 inhibitors work for vascular ED, but if testosterone is low, prolactin is high, or thyroid is failing—the pill won't fully fix it. You need the biology corrected.
3. Comprehensive testing changes outcomes. Testing just testosterone misses prolactin, thyroid, cortisol, glucose, and cardiovascular markers. A full panel reveals the real problem.
4. Sexual dysfunction is an early warning sign. ED predicts heart disease and stroke. Low libido signals hormonal decline or metabolic disease. Fixing sexual health often improves overall health too.
5. Monitoring ensures the protocol works. Retest every 8–12 weeks. Adjust based on new biomarkers and symptoms. Sexual function improves when biology is optimized and monitored.
Evidence

Research backing this guide

Testosterone and erectile function. Araujo AB, et al. (2007). The Journal of Sexual Medicine. Low testosterone predicts erectile dysfunction independent of age; relationship is causal.
Prolactin and sexual dysfunction. Graziottin A, et al. (2008). Nature Reviews Endocrinology. Elevated prolactin directly suppresses libido, erectile function, and sperm production.
Thyroid dysfunction and sexual health. Krysiak R, et al. (2014). The Journal of Clinical Endocrinology & Metabolism. Both hypothyroidism and hyperthyroidism impair sexual function; correction restores normal sexual response.
ED as a cardiovascular warning sign. Montorsi F, et al. (2005). European Heart Journal. ED is an independent predictor of cardiovascular events; often the first sign of vascular disease.
Cortisol and sexual dysfunction. Katz SS, et al. (2014). Hormones and Behavior. Chronic stress and elevated cortisol suppress testosterone production and sexual arousal.
Questions

Frequently asked about sexual health

What causes erectile dysfunction?
ED has multiple biological drivers, rarely just 'performance anxiety'. Low testosterone, elevated prolactin, thyroid dysfunction, poor blood pressure control, high cortisol, and cardiovascular disease all manifest as erectile difficulty. Metabolic markers matter: low magnesium, poor glucose control, and inflammation predict ED. Many men waste money on sildenafil without addressing the root cause. Testing reveals whether your ED is hormonal, vascular, neurological, or stress-driven. Treatment differs for each.
Can low libido be fixed without medication?
Sometimes, but only if you identify the cause. If libido is low due to sleep deprivation, chronic stress, or poor fitness, lifestyle changes alone may restore it. If testosterone is genuinely low, or prolactin is elevated, or thyroid is failing—medication or hormone optimization is needed. Guessing wastes time. Testing for testosterone, free testosterone, prolactin, thyroid (TSH, T3, T4), and cortisol reveals whether you have a treatable biological problem or a lifestyle issue.
What is premature ejaculation and how is it treated?
PE is ejaculation that occurs sooner than desired, often linked to low serotonin, high dopamine sensitivity, or anxiety. Biomarker testing checks for serotonin dysfunction, thyroid issues (can worsen PE), and elevated cortisol (anxiety marker). Treatment may include dapoxetine (SSRI designed for PE), serotonin optimization through diet/supplementation, and addressing underlying hormonal imbalances. PE is highly treatable when you identify the biological driver.
Does thyroid affect sexual function?
Yes, significantly. Hypothyroidism (low thyroid) causes fatigue, low libido, mood depression, and reduces sexual interest. Hyperthyroidism (high thyroid) can cause anxiety, restlessness, and performance issues. Thyroid hormone directly affects testosterone metabolism and sexual responsiveness. Many men with 'low libido' actually have undiagnosed thyroid dysfunction. Testing TSH, free T3, and free T4 reveals if thyroid is the culprit. Correcting thyroid function often restores sexual function.
How does cortisol affect sexual performance?
Chronically elevated cortisol suppresses testosterone production, reduces sexual arousal, and increases anxiety—all enemies of sexual function. Men under chronic stress often experience ED, low libido, and difficulty reaching orgasm. Cortisol also shifts blood flow toward stress response systems and away from reproductive function. Testing cortisol (morning + evening pattern) and prolactin (which rises with stress) reveals if stress hormones are the driver. Stress management, sleep optimization, and meditation directly improve sexual function.
What biomarkers matter for sexual health?
Essential markers include testosterone (total + free), SHBG (determines testosterone availability), prolactin (suppresses sexual desire), thyroid (TSH, T3, T4), cortisol (stress suppresses libido), estradiol (balance is critical), DHEA-S (drives sexual motivation), glucose + insulin (metabolic health), inflammatory markers (CRP), and blood pressure equivalents. Add magnesium, zinc, B12, and vitamin D—micronutrient deficiencies directly impair sexual function. arq. tests 100+ biomarkers to build a complete picture of your sexual health.
Is sexual dysfunction a sign of deeper health problems?
Absolutely. Sexual dysfunction is often an early warning sign of metabolic disease, cardiovascular disease, hormonal imbalance, or chronic stress. ED, for example, predicts heart attack and stroke—blood vessel dysfunction in the penis mirrors vascular disease elsewhere. Low libido signals declining testosterone, thyroid problems, or mental health issues. Rather than treat only the sexual symptom, testing identifies the underlying metabolic or hormonal problem. Fixing the root cause improves both sexual function and overall health.
How does arq. approach sexual health?
arq. begins with comprehensive bloodwork—100+ biomarkers including hormones, thyroid, metabolic markers, inflammation, and cardiovascular risk factors. A physician interprets your results in the context of your symptoms and sexual concerns. If testosterone is low, SHBG is blocking availability, prolactin is high, or thyroid is failing—we identify and address it. Treatment may include hormone optimization, medication (sildenafil, dapoxetine), lifestyle protocols, or supplement optimization. You're retested every 8–12 weeks to verify the protocol is working. Sexual health improves when biology is corrected.
Related Reading
Erectile Dysfunction
Biomarkers, treatment, and lasting solutions
ED Prescription Options in India
Sildenafil, tadalafil, and personalized protocols
Low Testosterone & TRT
Testing, diagnosis, and hormone optimization
Thyroid Health
How thyroid dysfunction affects sexual function

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